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BHF - Scientists make advances into regenerative medicine

American scientists have turned the scarred tissue that forms after a heart attack into heart muscle cells, using a new process that could potentially be used to repair a damaged heart.

The study used molecules called microRNAs to trigger the conversion of scar cells into heart muscle-like cells in the laboratory and also in a living mouse.

Dr Hélène Wilson, BHF's Research Advisor said:

We fund groundbreaking research that could literally ‘mend broken hearts’ in as little as ten years time

“This research represents a step forward in the quest to find a way to repair a damaged heart. The scientists claim to have directly transformed scarred heart tissue into heart muscle cells. This represents a significant advance in this field of research, but much more research will be needed before findings in the lab can be translated into the clinic.

“Interestingly, this study used microRNAs, which are short molecules similar to our DNA. These are found in many human cell types, so they are a really useful resource for this type of medicine.

“Repairing damaged heart muscle is the main objective of the BHF’s Mending Broken Hearts appeal, which funds groundbreaking research that could literally ‘mend broken hearts’ in as little as ten years time.”

This study was published in journal Circulation Research.

 
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