National Institute for Health and Clinical Excellence (NICE)
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Pregnant women to be offered first test to help diagnose pre-eclampsia

Midwives caring for pregnant women can use one of four blood tests to help diagnose suspected preterm pre-eclampsia, NICE has said in new draft diagnostic guidance.

The independent NICE diagnostic advisory committee has recommended four tests that can be used between 20 to 36 weeks and 6 days of pregnancy to help make decisions about caring for women presenting with suspected preterm pre-eclampsia.

Pre‑eclampsia is a potentially serious complication of pregnancy, thought to be related to problems with the development of the placenta.

Early signs of pre‑eclampsia include high blood pressure and having protein in the urine. Pre-eclampsia affects up to 6% of pregnancies, with severe pre-eclampsia developing in around 1-2% of UK pregnancies.

The recommended tests measure levels of placental growth factor (PLGF) in the blood. PLGF is a protein that helps the development of new blood vessels in the placenta. In pre-eclampsia levels of PLGF can be abnormally low and could be an indicator that the placenta is not developing properly.

Tests were previously only recommended by NICE for use to help rule out pre-eclampsia. Being able to help positively diagnose pre-eclampsia will lead to better care for the mother and her unborn baby. This can involve referral to a specialist and hospital admission to monitor the mother and unborn baby. Pre-eclampsia is only cured by delivery of the baby. Evidence presented to the committee showed that use of the tests did not lead to unnecessary early delivery.

If not monitored and treated, the condition can lead to serious complications for both mother and baby.

Recommendations on pre-eclampsia in NICE’s antenatal care guideline include measuring blood pressure and checking the urine for protein at each antenatal visit to check for pre-eclampsia. The guideline also recommends determining risk factors for pre-eclampsia at the booking appointment (by 10 weeks of pregnancy).

Jeanette Kusel, acting director for MedTech and digital at NICE, recently said:

“These tests represent a step change in the management and treatment of pre‑eclampsia.

“New evidence presented to the committee shows that these tests can help successfully diagnose pre‑eclampsia, alongside clinical information for decision-making, rather than just rule it out.

“This is extremely valuable to doctors and expectant mothers as now they can have increased confidence in their treatment plans and preparing for a safe birth.”

Dr Mark Kroese, chair of the NICE diagnostics advisory committee, recently said:

“The committee called for further research when it looked at this topic in 2016. Following some excellent research, we can now issue draft guidance for four test which the NHS can use to help diagnose pre‑eclampsia.”

A consultation on the draft recommendation is now open. Comments must be submitted via before Tuesday 19 April 2022.


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