The NCSC recommends following vendor best practice advice in the mitigation of vulnerabilities. In this case, the most important aspect is to install the latest updates immediately.
More information about the security updates can be found on Microsoft's website.
The Microsoft Exchange Server team has published a blog about these updates, which provides a script to obtain an inventory of the patch-level status of Exchange servers on premises. It also assists with some basic questions about installing the security updates.
Further information, including IOCs and detections, can be found in the Microsoft blogs: