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New rapid test to speed up TB diagnosis and treatment

Scientists at the Health Protection Agency have designed a new test which will identify positive tuberculosis (TB) cases within one hour, according to findings presented at the HPA's annual conference - Health Protection 2010 - at the University of Warwick yesterday.

Rapid detection of the TB bacteria (Mycobacterium tuberculosis) will ensure quick treatment for patients and could dramatically reduce the incidence and consequences of TB in the UK and worldwide if practised universally.

The standard identification test for TB can take anything up to eight weeks to grow and identify the bacteria. Other rapid molecular tests currently available target a particular element (called IS6110) which is normally present in TB bacteria. However, research has shown that this element is sometimes only present in very low amounts or in some cases lacking altogether in some strains of TB currently circulating. This has the effect of potentially lowering test sensitivity overall.

To combat this problem, HPA scientists have now developed a new ultra rapid test which substantially increases the sensitivity of the test, enabling detection of the presence of the bacteria in a sample within an hour. The new technique is a single DNA molecule identification test which uses real-time polymerase chain reaction (PCR). PCR is a technique used in molecular biology to amplify copies of a piece of DNA and generate millions of copies of that particular DNA sequence, enabling more DNA to be tested.

In 2008 in the UK, 8,655 cases of TB were reported. The main burden of disease was concentrated in major urban areas with 39% of cases reported in London. Almost three quarters of cases continue to occur in people born outside the UK (72%) and those aged 15-44 years (61%). Most of the non-UK-born patients were diagnosed two or more years after entry into the UK (77%).

Study author Dr Cath Arnold, head of the HPA's genomic services unit said:

"We're excited to have developed this new test because it means we can potentially diagnose someone at a TB clinic within an hour and start them immediately on the treatment they need. This new test could really have an impact where it is most needed.

"More than two thirds of TB infections in the UK are in non-UK born residents and other hard to reach groups concentrated in urban areas. Some of the population groups affected by tuberculosis include homeless people and transient non-UK-born patients who often travel between countries potentially disrupting treatment. This combined with the current long wait for a diagnosis can affect a patient's health outcomes and increase the risks of onward transmission of the infection."

Trials are currently planned in laboratories across the UK being rolled out over the next year to evaluate the test further against those currently used and additional research looking at streamlining the process is also needed.

Justin McCracken, HPA's chief executive, said:

"Reducing the stress of waiting for test results and diagnosing a patient immediately will certainly benefit the way TB is treated in UK. This is truly pioneering research and we look forward to the results of future trials that will hopefully result in the roll out a new test that will have an impact on the incidence of the infection not only in the UK but globally."

Notes to editors:

TB is an infectious disease primarily caused by Mycobacterium tuberculosis. Symptoms of the infection include:

  • Fever and night sweats
  • Persistent cough
  • Weight loss
  • Blood in your sputum (phlegm or spit) at any time

For more information on TB from the 2009 Annual Report and for the provisional data for 2009 please go to the HPA website.

For more information, please call the conference press office on 02476 572982.
Alternatively the national HPA press office can be reached on 0208 327 7098/7750 or email
cfipressoffice@hpa.org.uk

About Health Protection 2010
The Health Protection Agency's annual conference - Health Protection 2010 - is being held at the University of Warwick from 14-15 September. The conference offers a variety of innovative presentations which will demonstrate the latest scientific research and its practical application in three key areas of health protection - preventing and reducing infectious diseases, minimising the impact of radiation, chemical and environmental hazards and preparing for potential or emerging threats to health. To find out more information visit
www.healthprotectionconference.co.uk


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